Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592289 | 0.89 | ATM (0.41) | CASP3CASP7MAPTLMNAALDH1A1 | |
| SCHEMBL3990845 | 0.86 | KCNA5 (0.42) | KCNA5KCNH2CASP3CASP7MAPT | |
| SCHEMBL3988359 | 0.85 | LMNA (0.43) | KCNA5KCNH2CASP3CASP7MAPT | |
| SCHEMBL13792676 | 0.85 | LMNA (0.43) | KCNA5KCNH2CASP3CASP7MAPT | |
| SCHEMBL3996325 | 0.83 | NPBWR1 (0.43) | KCNA5KCNH2LMNAALDH1A1NPBWR1 | |
| SCHEMBL3996224 | 0.81 | DRD2 (0.37) | CASP3CASP7LMNAALDH1A1PKM | |
| SCHEMBL26103002 | 0.77 | GRM2 (0.51) | LMNAALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL3994875 | 0.74 | PPARA (0.39) | KCNA5ALDH1A1PKMNPBWR1 | |
| SCHEMBL3987812 | 0.72 | LMNA (0.45) | CASP3CASP7MAPTLMNAALDH1A1 | |
| SCHEMBL15757876 | 0.71 | GRM2 (0.53) | MAPTLMNAALDH1A1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544812-B2 | For example, 2-(4-{2-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid, 2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoky)-2-methyl-propionic acid; for treating diabetes mellitus | ELI LILLY AND COMPANY (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544812-B2 | For example, 2-(4-{2-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid, 2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoky)-2-methyl-propionic acid; for treating diabetes mellitus | ELI LILLY AND COMPANY (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544812-B2 | For example, 2-(4-{2-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid, 2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoky)-2-methyl-propionic acid; for treating diabetes mellitus | ELI LILLY AND COMPANY (US) | 2009-06-09 | — | — | US | disclosed |
| US-20050020652-A1 | Peroxisome proliferator activated receptor agonists | ELI LILLY AND COMPANY | 2005-01-27 | — | — | US | disclosed |
| EP-1453811-A2 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003048130-A2 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020652-A1 | Peroxisome proliferator activated receptor agonists | PPARA, PPARD, PPARG | KCNA5 3674/4885KCNH2 2660/4885CASP3 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.