Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 17/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CPT2 | P23786 | 1/20 | 0.48 |
| ▸ | CPT1A | P50416 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984104 | 0.82 | CCR1 (0.67) | CCR1PKMHTTSMN1; SMN2CPT2 | |
| SCHEMBL3984106 | 0.82 | CCR1 (0.67) | CCR1PKMHTTSMN1; SMN2CPT2 | |
| SCHEMBL9910985 | 0.81 | CCR1 (0.73) | CCR1PKMHTTSMN1; SMN2CPT2 | |
| SCHEMBL14306232 | 0.81 | CCR1 (0.75) | CCR1CPT2CPT1A | |
| SCHEMBL3987554 | 0.81 | CCR1 (0.66) | CCR1PKMHTTSMN1; SMN2CPT2 | |
| SCHEMBL3987553 | 0.81 | CCR1 (0.66) | CCR1PKMHTTSMN1; SMN2CPT2 | |
| SCHEMBL14304108 | 0.81 | CCR1 (0.71) | CCR1PKMHTTSMN1; SMN2CPT2 | |
| SCHEMBL14313691 | 0.79 | CCR1 (0.72) | CCR1PKMHTTSMN1; SMN2CPT2 | |
| SCHEMBL14306239 | 0.78 | CCR1 (0.92) | CCR1 | |
| SCHEMBL14304103 | 0.78 | CCR1 (1.00) | CCR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059502-A2 | PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008011392-A2 | PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION | LIGAND PHARMACUETICALS INCORPORATED (US) | 2008-01-24 | — | — | WO | disclosed |