Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644461 | 1.00 | GAA (0.65) | GAAMAPTBACE1KDM4EHSD17B10 | |
| SCHEMBL29569853 | 1.00 | GAA (0.65) | GAAMAPTBACE1KDM4EHSD17B10 | |
| SCHEMBL926891 | 1.00 | GAA (0.65) | GAAMAPTBACE1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL7950878 | 0.98 | GAA (0.63) | GAAMAPTBACE1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL30046451 | 0.98 | GAA (0.63) | GAAMAPTBACE1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL6397031 | 0.98 | GAA (0.63) | GAAMAPTBACE1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL926973 | 0.98 | GAA (0.63) | GAAMAPTBACE1KDM4EHSD17B10 | |
| Methyl Alcohol SCHEMBL28795455 | 0.98 | GAA (0.63) | GAAMAPTBACE1KDM4EHSD17B10 | |
| SCHEMBL3256392 | 0.87 | GAA (0.61) | GAAMAPTKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL7294748 | 0.84 | GAA (0.61) | GAAMAPTEPHX2SMYD3MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110592045-B | Recombinant esterase, gene, engineering bacterium and application of recombinant esterase to resolution of (R, S) -indoline-2-ethyl formate | 浙江工业大学 | 2021-04-06 | — | — | CN | disclosed |
| CN-109762768-B | Bacillus B8W22 and application thereof | 浙江工业大学 | 2020-08-21 | — | — | CN | disclosed |
| CN-110592045-A | Recombinant esterase, gene, engineering bacterium and application of recombinant esterase to resolution of (R, S) -indoline-2-ethyl formate | 浙江工业大学 | 2019-12-20 | — | — | CN | disclosed |
| EP-1687270-A4 | METHOD FOR PREPARING (S)-INDOLINE-2-CARBOXYLIC ACID AND (S)-INDOLINE-2-CARBOXYLIC ACID METHYL ESTER USING HYDROLYTIC ENZYME | SK HOLDINGS CO LTD (KR) | 2009-05-20 | — | — | EP | disclosed |
| CN-100463903-C | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme | SK CORP (KR) | 2009-02-25 | — | — | CN | disclosed |
| US-7405070-B2 | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme | SK CORPORATION (KR) | 2008-07-29 | — | — | US | disclosed |
| US-20070077632-A1 | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme | SK CORPORATION (KR) | 2007-04-05 | — | — | US | disclosed |
| CN-1886373-A | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme | SK CORP (KR) | 2006-12-27 | — | — | CN | disclosed |
| EP-1687270-A1 | METHOD FOR PREPARING (S)-INDOLINE-2-CARBOXYLIC ACID AND (S)-INDOLINE-2-CARBOXYLIC ACID METHYL ESTER USING HYDROLYTIC ENZYME | SK Corporation (KR) | 2006-08-09 | — | — | EP | disclosed |
| US-7034051-B2 | Fused bicyclic carboxamide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2006-04-25 | — | — | US | disclosed |
| WO-2005051910-A1 | METHOD FOR PREPARING (S)-INDOLINE-2-CARBOXYLIC ACID AND (S)-INDOLINE-2-CARBOXYLIC ACID METHYL ESTER USING HYDROLYTIC ENZYME | SK CORPORATION (KR) | 2005-06-09 | — | — | WO | disclosed |
| US-20050054630-A1 | Fused bicyclic carboxamide derivatives and methods of their use | CUBIST PHARMACEUTICALS, INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054630-A1 | Fused bicyclic carboxamide derivatives and methods of their use | PAICS, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CPS1 | GAA 637/4885MAPT 2386/4885BACE1 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.