⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991422 | 1.00 | — | — | |
| SCHEMBL3989203 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL5566160 | 0.98 | CA1 (0.55) | — | |
| SCHEMBL1627445 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL661205 | 0.85 | CA1 (0.45) | — | |
| SCHEMBL184812 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL28089024 | 0.82 | CA2 (0.64) | — | |
| SCHEMBL4845983 | 0.82 | CA2 (0.64) | — | |
| SCHEMBL28089225 | 0.82 | CA2 (0.64) | — | |
| SCHEMBL2706951 | 0.81 | CPB2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103159660-B | (2R)-1-(2-methyl-3-(methoxyl group (methyl) amino)-propiono) pyrrolidine-2-carboxylic acid and application thereof | 天津市国际生物医药联合研究院 | 2016-07-06 | — | — | CN | claimed |
| CN-103159660-A | (2R)-1-(2-methyl-3-(methoxy(methyl)amino)-propionyl)pyrrolidine-2-carboxylic acid and application thereof | TIANJIN INT JOINT ACADEMY BIOTECHNOLOGY & MEDICINE | 2013-06-19 | — | — | CN | claimed |
| US-12351575-B2 | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2025-07-08 | — | — | US | disclosed |
| US-20200317660-A1 | Quinazolinone Compound and Application Thereof | Luoxin Healthcare Science and Technology Development (Beijing) Ltd. (CN) | 2020-10-08 | — | — | US | disclosed |
| US-20200062753-A1 | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2020-02-27 | — | — | US | disclosed |
| US-10428069-B2 | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2019-10-01 | — | — | US | disclosed |
| CN-109232613-A | For treating and preventing the condensed heteroaryl dihydro-pyrimidin of hepatitis b virus infected new 6- | 豪夫迈·罗氏有限公司 | 2019-01-18 | — | — | CN | disclosed |
| EP-3114128-B1 | NOVEL 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2019-01-02 | — | — | EP | disclosed |
| US-20180370969-A1 | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2018-12-27 | — | — | US | disclosed |
| CN-106061978-B | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infections | 豪夫迈·罗氏有限公司 | 2018-10-23 | — | — | CN | disclosed |
| US-10081627-B2 | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2018-09-25 | — | — | US | disclosed |
| US-20090291938-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
| WO-2009067547-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | WO | disclosed |
| CN-1926241-A | Process for preparing enantiomerically enriched beta-2-amino acids using enzymes | DSM IP ASSETS BV (NL) | 2007-03-07 | — | — | CN | disclosed |
| EP-1745137-A1 | ENZYMATIC PREPARATION OF AN ENANTIOMERICALLY ENRICHED BETA-2-AMINO ACIDS | DSMIP Assets B.V. (NL) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005085462-A1 | ENZYMATIC PREPARATION OF AN ENANTIOMERICALLY ENRICHED BETA-2-AMINO ACIDS | DSM IP ASSETS B.V. (NL) | 2005-09-15 | — | — | WO | disclosed |
| WO-2002066417-A1 | METHOD FOR THE PRODUCTION OF THE ENANTIOMERS OF 2-SUBSTITUTED BETA AMINO ACIDS | CHIROBLOCK GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |
| US-5939398-A | ANTIATHEROSCLEROSIS AGENTS | PFIZER INC. (US) | 1999-08-17 | — | — | US | disclosed |
| EP-0737202-A1 | HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018143-A1 | HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1995-07-06 | — | — | WO | disclosed |