Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.60 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.59 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544193 | 0.82 | LOXL2 (0.70) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| SCHEMBL31276343 | 0.82 | LOXL2 (0.70) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| SCHEMBL6000185 | 0.82 | LOXL2 (0.70) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| SCHEMBL5885636 | 0.81 | LOXL2 (0.56) | LOXL2CYP4F2CYP4A11MAPTKDM4E | |
| SCHEMBL3622638 | 0.80 | LOXL2 (0.66) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| SCHEMBL1715330 | 0.80 | LOXL2 (0.71) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| SCHEMBL126284 | 0.79 | LOXL2 (0.74) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| SCHEMBL70173 | 0.79 | CYP4F2 (0.83) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| SCHEMBL6667451 | 0.78 | LOXL2 (0.64) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT | |
| Hydrochloric Acid SCHEMBL1715819 | 0.78 | LOXL2 (0.69) | LOXL2CYP4F2CYP4A11MRGPRX4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140079-B1 | ASSAYS FOR LIGANDS FOR NUCLEAR RECEPTORS | GLAXO GROUP LTD (GB) | 2009-06-03 | — | — | EP | disclosed |
| US-6984650-B2 | Use of FXR ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2006-01-10 | — | — | US | disclosed |
| EP-1140079-A4 | ASSAYS FOR LIGANDS FOR NUCLEAR RECEPTORS | GLAXO GROUP LTD (GB) | 2004-06-09 | — | — | EP | disclosed |
| US-20040048316-A1 | Assays for ligands for nuclear receptors | HAFFNER CURT DALE (US) | 2004-03-11 | — | — | US | disclosed |
| US-6639078-B1 | Assays for ligands for nuclear receptors | SMITHKLINE BEECHAM CORPORATION | 2003-10-28 | — | — | US | disclosed |
| EP-1140079-A1 | ASSAYS FOR LIGANDS FOR NUCLEAR RECEPTORS | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037077-A1 | ASSAYS FOR LIGANDS FOR NUCLEAR RECEPTORS | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048316-A1 | Assays for ligands for nuclear receptors | NCOA1, NCOA3, NCOR1 | LOXL2 4548/4885CYP4F2 795/4885CYP4A11 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.