SCHEMBL6667451

SCHEMBL6667451

COC(=O)c1cccc(COCc2ccccc2)c1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.64
CYP4F2 P78329 2/20 0.62
CYP4A11 Q02928 2/20 0.62
SLC7A5 Q01650 1/20 0.58
MRGPRX4 Q96LA9 3/20 0.58
HPGD P15428 2/20 0.57
LMNA P02545 1/20 0.57
RAB9A P51151 4/20 0.57
ALDH1A1 P00352 2/20 0.57
KDM4E B2RXH2 1/20 0.57
MAPT P10636 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
TSHR P16473 2/20 0.56
HIF1A Q16665 1/20 0.56
FOLH1 Q04609 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6000185 0.95 LOXL2 (0.70) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4
SCHEMBL10235310 0.92 MAPT (0.63) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4
SCHEMBL14505830 0.89 HPGD (0.63) LOXL2CYP4F2CYP4A11SLC7A5HPGD
SCHEMBL11439089 0.88 LOXL2 (0.57) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4
SCHEMBL6669062 0.86 RAB9A (0.75) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4
SCHEMBL28869399 0.86 LOXL2 (0.62) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4
SCHEMBL7612280 0.85 LOXL2 (0.54) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4
SCHEMBL9233919 0.85 TSHR (0.62) LOXL2HPGDLMNARAB9AMAPT
SCHEMBL31276343 0.85 LOXL2 (0.70) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4
SCHEMBL1544193 0.85 LOXL2 (0.70) LOXL2CYP4F2CYP4A11SLC7A5MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1004621-B1 GAMMA-RAY STABILIZER AND THERMOPLASTIC POLYMER COMPOSITION CONTAINING THE SAME TEIJIN CHEMICALS LTD (JP) 2004-09-15 EP disclosed
US-6485657-B1 Gamma-ray stabilizer and thermoplastic polymer compound including the said stabilizer TEIJIN, LIMITED (JP) 2002-11-26 US disclosed
EP-1004621-A1 GAMMA-RAY STABILIZER AND THERMOPLASTIC POLYMER COMPOSITION CONTAINING THE SAME TEIJIN LIMITED (JP) 2000-05-31 EP disclosed