Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372022 | 0.79 | NMT1 (0.57) | NMT1F2L3MBTL1AVPR1BNR3C1 | |
| SCHEMBL4080617 | 0.71 | F2 (0.56) | NMT1F2AVPR1BAVPR1AALDH1A1 | |
| SCHEMBL3818528 | 0.69 | F2 (0.41) | NMT1F2AVPR1BNR3C1PGR | |
| SCHEMBL1935802 | 0.67 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1PKMKMT2A | |
| SCHEMBL31187890 | 0.66 | ACHE (0.48) | ALDH1A1 | |
| SCHEMBL2372018 | 0.65 | NMT1 (0.56) | NMT1F2AVPR1BNR3C1PGR | |
| SCHEMBL13663687 | 0.65 | NMT1 (0.49) | NMT1F2AVPR1BNR3C1PGR | |
| SCHEMBL28928134 | 0.64 | CYP1A2 (0.39) | ALDH1A1 | |
| SCHEMBL6390711 | 0.64 | AVPR1B (0.53) | NMT1F2AVPR1BAVPR1A | |
| SCHEMBL15157449 | 0.64 | F2 (0.56) | NMT1F2NR3C1PGRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606288-B1 | BENZENESULPHONAMIDE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF FOR TREATMENT OF PAIN | FOURNIER LAB SA (FR) | 2009-06-03 | — | — | EP | disclosed |
| WO-2007140383-A2 | SPIROCYCLIC SULFONAMIDES AND RELATED COMPOUNDS | NEUROGEN CORPORATION (US) | 2007-12-06 | — | — | WO | disclosed |
| EP-1606288-A1 | BENZENESULPHONAMIDE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF FOR TREATMENT OF PAIN | LABORATOIRES FOURNIER S.A. (FR) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004087700-A1 | BENZENESULPHONAMIDE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF FOR TREATMENT OF PAIN | LABORATOIRES FOURNIER S.A. (FR) | 2004-10-14 | — | — | WO | disclosed |