Benzamide

Benzamide

SCHEMBL3994635

NC(=O)c1ccccc1.O=C(OC(F)(F)F)C(F)(F)F

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.57
MAPT P10636 2/20 0.57
POLB P06746 1/20 0.57
CYP3A4 P08684 1/20 0.57
TSHR P16473 1/20 0.57
CYP2C19 P33261 1/20 0.57
RECQL P46063 1/20 0.57
BLM P54132 1/20 0.57
PMP22 Q01453 1/20 0.57
HSD17B10 Q99714 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
CES1 P23141 1/20 0.47
PARP10 Q53GL7 9/20 0.46
PLA2G10 O15496 1/20 0.42
PLA2G2A P14555 1/20 0.42
MAOB P27338 2/20 0.40
PARP15 Q460N3 4/20 0.38
PARP14 Q460N5 3/20 0.38
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzamide SCHEMBL29494570 0.81 PARP1 (0.73) PARP1MAPTPOLBCYP3A4TSHR
Benzamide SCHEMBL9005948 0.81 PARP1 (0.73) PARP1MAPTPOLBCYP3A4TSHR
Benzamide SCHEMBL1786300 0.81 PARP1 (0.73) PARP1MAPTPOLBCYP3A4TSHR
Benzamide SCHEMBL6690447 0.76 PARP1 (1.00) PARP1MAPTPOLBCYP3A4TSHR
SCHEMBL21755166 0.76 PARP1 (1.00) PARP1MAPTPOLBCYP3A4TSHR
Benzamide SCHEMBL1222101 0.76 PARP1 (1.00) PARP1MAPTPOLBCYP3A4TSHR
Benzamide SCHEMBL29618402 0.76
Benzamide SCHEMBL1332331 0.76
Benzamide SCHEMBL16352 0.76
Benzamide SCHEMBL30112947 0.76 PARP1 (1.00) PARP1MAPTPOLBCYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101693695-A Pyrimidine derivatives and methods of treatment related to their use ARENA PHARM INC 2010-04-14 CN disclosed
CN-101475528-A Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof TAISHO PHARMACEUTICAL CO LTD (JP) 2009-07-08 CN disclosed
WO-2009072643-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-06-11 WO disclosed
CN-100475793-C Quinazoline derivatives and use for preparing medicine TAISHO PHARMACEUTICAL CO LTD (JP) 2009-04-08 CN disclosed
CN-100451004-C Pyrimidine derivatives ARENA PHARM INC (JP) 2009-01-14 CN disclosed
CN-1976905-A Pyrimidine derivatives and methods of treatment related to their use TAISHO PHARMACEUTICAL CO LTD (JP) 2007-06-06 CN disclosed
EP-1606255-A4 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2007-02-07 EP disclosed
EP-1483241-A4 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2006-12-13 EP disclosed
CN-1798736-A Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use ARENA PHARM INC (JP) 2006-07-05 CN disclosed
CN-1795180-A Novel quinazoline derivatives and methods of treatment related to the use thereof TAISHO PHARMACEUTICAL CO LTD (JP) 2006-06-28 CN disclosed
EP-1606255-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2005-12-21 EP disclosed
EP-1483241-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2004-12-08 EP disclosed
WO-2004071460-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2004-08-26 WO disclosed
WO-2003075853-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2003-09-18 WO disclosed