Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | GOT1 | P17174 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | MAOA | P21397 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | MPO | P05164 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | AOX1 | Q06278 | 1/20 | 1.00 |
| ▸ | ACOX1 | Q15067 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydralazine SCHEMBL7810 | 1.00 | ALDH1A1 (1.00) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL36271 | 0.98 | GOT1 (1.00) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL27864907 | 0.98 | GOT1 (1.00) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL1173534 | 0.98 | GOT1 (1.00) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL1650561 | 0.96 | ALDH1A1 (0.93) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Dihydralazine SCHEMBL13724517 | 0.96 | ALDH1A1 (0.93) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL2780318 | 0.94 | ALDH1A1 (0.89) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL2781885 | 0.90 | NPC1 (0.81) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL8703662 | 0.90 | ALDH1A1 (0.81) | ALDH1A1NPC1RAB9AGOT1LMNA | |
| Hydralazine SCHEMBL2779460 | 0.90 | NPC1 (0.81) | ALDH1A1NPC1RAB9AGOT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063875-A2 | COMBINATION PHARMACEUTICAL COMPOSITIONS | Sigmoid Pharma Limited (IE) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008132712-A2 | COMBINATION PHARMACEUTICAL COMPOSITIONS | SIGMOID PHARMA LIMITED (IE) | 2008-11-06 | — | — | WO | disclosed |