Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | AGER | Q15109 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10782316 | 0.85 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HPGDCA1CA2 | |
| SCHEMBL3658766 | 0.85 | CA1 (0.47) | ALDH1A1SMN1; SMN2HTTHPGDCA1 | |
| SCHEMBL29618392 | 0.84 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HTTHPGDCA1 | |
| SCHEMBL15797599 | 0.84 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL31464258 | 0.83 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2HTTHPGDCA1 | |
| SCHEMBL7317043 | 0.83 | PYGL (0.55) | ALDH1A1SMN1; SMN2HTTHPGDCA1 | |
| SCHEMBL130152 | 0.83 | HTT (0.72) | ALDH1A1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL3659229 | 0.82 | CA1 (0.49) | ALDH1A1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL21003306 | 0.82 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2HTTHPGDGAA | |
| Hydrochloric Acid SCHEMBL7413426 | 0.82 | GAA (0.47) | ALDH1A1SMN1; SMN2HTTHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591278-A | Preparation method of 4-acetamido-5-chloro-2, 3-dihydrobenzofuran-7-carboxylic acid methyl ester | 鲁南制药集团股份有限公司 | 2022-06-07 | — | — | CN | claimed |
| CN-107337658-A | A kind of synthetic method of the chloro- 2,3- Dihydrobenzofuranes -7- carboxylic acids of butanedioic acid prucalopride intermediate 4- amino -5- | 沈阳药科大学 | 2017-11-10 | — | — | CN | claimed |
| CN-119241461-A | Mosapride citrate impurity compound and preparation method thereof | 吉林修正药业新药开发有限公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-114437007-B | Preparation method of prizepride intermediate | 鲁南制药集团股份有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-115745929-B | Preparation method of prizepine succinate key intermediate | 山东四环药业股份有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-112920132-B | Small-molecule non-nucleoside compound serving as immunomodulator | 齐鲁师范学院 | 2023-08-15 | — | — | CN | disclosed |
| CN-115745929-A | Preparation method of prankari succinate key intermediate | 山东四环药业股份有限公司 | 2023-03-07 | — | — | CN | disclosed |
| CN-115745928-A | Preparation method of prucalopride intermediate | 山东新时代药业有限公司 | 2023-03-07 | — | — | CN | disclosed |
| CN-114591278-A | Preparation method of 4-acetamido-5-chloro-2, 3-dihydrobenzofuran-7-carboxylic acid methyl ester | 鲁南制药集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-114591278-A | Preparation method of 4-acetamido-5-chloro-2, 3-dihydrobenzofuran-7-carboxylic acid methyl ester | 鲁南制药集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-114437007-A | Preparation method of prucalopride intermediate | 鲁南制药集团股份有限公司 | 2022-05-06 | — | — | CN | disclosed |
| WO-1989010364-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-11-02 | — | — | WO | disclosed |
| EP-0339950-A2 | Dibenzofurancarboxamides, their use as pharmaceutical agents, a composition containing the same, and a process for the preparation thereof | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4835172-A | Novel benzamides, intermediates and process for the preparation and therapeutic use thereof | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE (FR) | 1989-05-30 | — | — | US | disclosed |
| EP-0018830-B1 | SPIROBENZOFURANONES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Chemical Industries, Ltd. (JP) | 1983-06-08 | — | — | EP | disclosed |
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | disclosed |
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| EP-0018830-A2 | Spirobenzofuranones, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-11-12 | — | — | EP | disclosed |
| EP-0003084-A1 | Spirobenzofuranone compounds, processes for their preparation and their use as medicines | Takeda Chemical Industries, Ltd. (JP) | 1979-07-25 | — | — | EP | disclosed |