Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Melatonin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A known ✓ | P48039 | 10/20 | 0.58 |
| ▸ | MTNR1B known ✓ | P49286 | 8/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NQO2 | P16083 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melatonin SCHEMBL17799776 | 0.78 | MTNR1A (0.78) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL4686085 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL8060688 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL29349848 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL19018 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL28743439 | 0.75 | MTNR1A (0.97) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL3845735 | 0.75 | MTNR1A (0.97) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL28895534 | 0.75 | MTNR1A (0.97) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL28400730 | 0.75 | MTNR1A (0.97) | MTNR1AMTNR1BTDP1KMT2AMEN1 | |
| Melatonin SCHEMBL8850894 | 0.75 | MTNR1A (0.97) | MTNR1AMTNR1BTDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073686-A1 | AGENT DELIVERY SYSTEM AND USES OF THE SAME | TRANS DERMAL PATENTS COMPANY, LLC (US) | 2009-06-11 | — | — | WO | disclosed |
| US-20090143761-A1 | AGENT DELIVERY SYSTEM AND USES OF SAME | TRANSDERMAL PATENTS COMPANY, LLC (US) | 2009-06-04 | — | — | US | disclosed |
| EP-1893278-A2 | AGENT DELIVERY SYSTEM | Trans-Dermal Patents Company, LLC (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133101-A9 | AGENT DELIVERY SYSTEM | TRANS DERMAL PATENTS COMPANY L (US) | 2007-03-15 | — | — | WO | disclosed |
| WO-2006133101-A2 | AGENT DELIVERY SYSTEM | TRANS-DERMAL PATENTS COMPANY, LLC (US) | 2006-12-14 | — | — | WO | disclosed |
| WO-2006133103-A2 | RESERVOIR FOR DELIVERY OF AGENTS | TRANS-DERMAL PATENTS COMPANY, LLC (US) | 2006-12-14 | — | — | WO | disclosed |
| WO-2006133102-A2 | AGENT DELIVERY SYSTEM AND USES OF THE SAME | TRANS-DERMAL PATENTS COMPANY, LLC (US) | 2006-12-14 | — | — | WO | disclosed |
| US-20050175505-A1 | Personal monitor to detect exposure to toxic agents | CANTOR HAL C (US) | 2005-08-11 | — | — | US | disclosed |
| EP-1495106-A2 | PERSONAL MONITOR TO DETECT EXPOSURE TO TOXIC AGENTS | Advanced Sensor Technologies, Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2004023105-A2 | PERSONAL MONITOR TO DETECT EXPOSURE TO TOXIC AGENTS | ADVANCED SENSOR TECHNOLOGIES, INC. (US) | 2004-03-18 | — | — | WO | disclosed |