Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21816340 | 0.81 | CAMKK1 (0.53) | NOTUMCAMKK1CAMKK2MGLLALDH1A1 | |
| SCHEMBL4000699 | 0.80 | PSMD14 (0.47) | NOTUMCAMKK1CAMKK2MGLLALDH1A1 | |
| SCHEMBL18638435 | 0.75 | CAMKK1 (0.38) | NOTUMCAMKK1CAMKK2MGLLUTS2R | |
| SCHEMBL29846854 | 0.75 | UTS2R (0.36) | P2RX7NOTUMCAMKK1CAMKK2MGLL | |
| SCHEMBL15890323 | 0.72 | L3MBTL1 (0.53) | MGLLALDH1A1UTS2RCYP3A4ADORA3 | |
| SCHEMBL18896257 | 0.72 | UTS2R (0.38) | NOTUMCAMKK1CAMKK2ALDH1A1UTS2R | |
| SCHEMBL2747728 | 0.72 | HDAC3 (0.52) | P2RX7MGLLALDH1A1MAPT | |
| SCHEMBL31083856 | 0.71 | NOTUM (0.43) | NOTUMCAMKK1CAMKK2MGLLUTS2R | |
| SCHEMBL4569763 | 0.70 | NOTUM (0.41) | NOTUMCAMKK1CAMKK2ALDH1A1UTS2R | |
| SCHEMBL2885548 | 0.70 | NCF1 (0.39) | NOTUMCAMKK1CAMKK2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071577-A1 | OXADIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071577-A1 | OXADIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2009-06-11 | — | — | WO | disclosed |