Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792040 | 0.85 | TSHR (0.61) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL11174747 | 0.81 | TSHR (0.85) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL11218123 | 0.78 | TSHR (0.70) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL524817 | 0.77 | CALM1 (0.65) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL18157879 | 0.77 | CALM1 (0.65) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL8221303 | 0.77 | CARM1 (0.67) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL11394833 | 0.73 | TSHR (0.64) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL24735547 | 0.73 | TSHR (1.00) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL5014268 | 0.73 | TSHR (1.00) | TSHRALDH1A1TAAR1HTR2ASLC6A4 | |
| SCHEMBL27766437 | 0.73 | TSHR (1.00) | TSHRALDH1A1TAAR1HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071888-A1 | PYRROLOTHIAZOLES AS PI3-KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |