Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997734 | 0.89 | L3MBTL1 (0.47) | L3MBTL1HPGDMAPK1ALDH1A1PDK2 | |
| SCHEMBL8028835 | 0.82 | L3MBTL1 (0.46) | TP53L3MBTL1HPGDMAPK1ALDH1A1 | |
| SCHEMBL4000871 | 0.80 | L3MBTL1 (0.38) | L3MBTL1ALDH1A1PDK2TDP1KDM4E | |
| SCHEMBL19078462 | 0.80 | HPGD (0.58) | L3MBTL1HPGDMAPK1ALDH1A1MEN1 | |
| SCHEMBL31497620 | 0.77 | HRH3 (0.53) | ALDH1A1MEN1KMT2APDK2MAPT | |
| SCHEMBL17609474 | 0.77 | ALDH1A1 (0.49) | HPGDALDH1A1MEN1KMT2APDK2 | |
| SCHEMBL3996895 | 0.76 | MAPT (0.48) | TP53L3MBTL1HPGDMAPK1ALDH1A1 | |
| SCHEMBL27164103 | 0.75 | TP53 (0.46) | TP53L3MBTL1HPGDMAPK1ALDH1A1 | |
| SCHEMBL17609445 | 0.75 | MAPT (0.53) | HPGDALDH1A1MEN1KMT2AATM | |
| SCHEMBL16648472 | 0.75 | MAPT (0.54) | L3MBTL1HPGDMAPK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |