Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.38 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.38 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.38 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624510 | 0.89 | CCR5 (0.42) | L3MBTL1CCR5KMT2AMAPK1MEN1 | |
| SCHEMBL4000653 | 0.82 | TP53 (0.47) | L3MBTL1KMT2AMAPK1MEN1KDM4E | |
| SCHEMBL3625792 | 0.81 | LMNA (0.38) | L3MBTL1CCR5KMT2AMEN1PTGER1 | |
| SCHEMBL3995161 | 0.80 | CCR5 (0.51) | CCR5KMT2AMAPK1MEN1PTGER1 | |
| SCHEMBL4000871 | 0.80 | L3MBTL1 (0.38) | L3MBTL1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3628788 | 0.80 | KMT2A (0.45) | L3MBTL1CCR5KMT2AMAPK1MEN1 | |
| SCHEMBL3997734 | 0.79 | L3MBTL1 (0.47) | L3MBTL1MAPK1KDM4EMAPTALDH1A1 | |
| SCHEMBL3997114 | 0.78 | ITGB2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1HPGD | |
| SCHEMBL17609412 | 0.77 | ALDH1A1 (0.41) | L3MBTL1CCR5KMT2AMAPK1MEN1 | |
| SCHEMBL17609408 | 0.74 | GUCY1B2 (0.46) | CCR5KMT2AMAPK1MEN1GUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |