Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 8/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996746 | 0.86 | TACR1 (0.44) | TACR1MMP8MMP13TSHRTRPV1 | |
| SCHEMBL3998209 | 0.84 | TACR1 (0.41) | TACR1MMP8MMP13TSHRTRPV1 | |
| SCHEMBL3998193 | 0.81 | TACR1 (0.43) | TACR1MMP8MMP13TSHRTRPV1 | |
| SCHEMBL3783405 | 0.78 | OPRK1 (0.42) | MMP8MMP13TSHRTRPV1KMT2A | |
| SCHEMBL3778720 | 0.75 | PARP1 (0.51) | MMP8MMP13TSHRTRPV1KMT2A | |
| SCHEMBL3786876 | 0.74 | HTR1A (0.45) | MMP8MMP13TRPV1KMT2ACCR2 | |
| SCHEMBL3779175 | 0.74 | PARP1 (0.47) | MMP8MMP13TSHRTRPV1KMT2A | |
| SCHEMBL3998191 | 0.74 | TRPV1 (0.36) | TACR1MMP8MMP13TRPV1KMT2A | |
| SCHEMBL3996741 | 0.73 | PARP1 (0.41) | MMP8MMP13TRPV1KMT2APARP1 | |
| SCHEMBL3029909 | 0.73 | TACR1 (0.59) | TACR1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076404-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | disclosed |