Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.66 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29653575 | 0.89 | F10 (0.62) | F10CNR2RAF1BRAF | |
| SCHEMBL4476981 | 0.88 | F10 (0.67) | F10 | |
| SCHEMBL5514263 | 0.88 | F10 (0.53) | F10CNR2 | |
| SCHEMBL5504459 | 0.88 | F10 (0.60) | F10CNR2RAF1BRAF | |
| SCHEMBL4465409 | 0.87 | F10 (0.59) | F10 | |
| SCHEMBL5217814 | 0.87 | F10 (0.59) | F10 | |
| SCHEMBL5508172 | 0.86 | F10 (0.59) | F10 | |
| SCHEMBL5512937 | 0.86 | F10 (0.51) | F10 | |
| SCHEMBL27691847 | 0.86 | F10 (0.61) | F10 | |
| SCHEMBL5516707 | 0.85 | F10 (0.51) | F10CNR2RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563786-B2 | Substituted thiophenecarboxamides, their preparation and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-21 | — | — | US | disclosed |
| US-7476663-B2 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |
| EP-1797080-A1 | NOVEL SUBSTITUTED THIOPHENCARBOXYLIC ACID AMIDES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2007-06-20 | — | — | EP | disclosed |
| EP-1747217-A1 | NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2006034822-A1 | NOVEL SUBSTITUTED THIOPHENCARBOXYLIC ACID AMIDES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-04-06 | — | — | WO | disclosed |
| US-20060069082-A1 | Novel substituted thiophenecarboxamides, their preparation and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-03-30 | — | — | US | disclosed |
| US-20050277628-A1 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-15 | — | — | US | disclosed |
| WO-2005111029-A1 | NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069082-A1 | Novel substituted thiophenecarboxamides, their preparation and their use as medicaments | P2RY11, P2RX5, TPMT | F10 2756/4885CNR2 8/4885RAF1 4662/4885 |
| US-20050277628-A1 | Substituted thiophene carboxamides | OTC, SLC22A8, DDC | F10 2132/4885CNR2 840/4885RAF1 3626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.