Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4002694 | 0.89 | SLC6A4 (0.39) | ABL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3997555 | 0.85 | REN (0.40) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3996199 | 0.84 | HTR2A (0.37) | GCKABL1HTR2ASLC6A2SLC6A4 | |
| SCHEMBL3997779 | 0.81 | SSTR5 (0.41) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4001474 | 0.81 | HTR1F (0.37) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3999681 | 0.81 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3997842 | 0.81 | PTK2 (0.37) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3997886 | 0.80 | ALOX15 (0.44) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3993849 | 0.78 | PDE4A (0.42) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4585576 | 0.78 | HTR1F (0.36) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | claimed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | claimed |
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | disclosed |