Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | HTR7 | P34969 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | PLD2 | O14939 | 1/20 | 0.34 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003775 | 0.82 | CCR3 (0.59) | CCR3HTR2ADRD2 | |
| SCHEMBL4001388 | 0.80 | CCR3 (0.40) | CCR3HTR2AHTR7KCNH2DRD2 | |
| SCHEMBL13797758 | 0.77 | CCR3 (0.56) | CCR3HTR2ADRD2 | |
| SCHEMBL27645802 | 0.76 | USP2 (0.49) | HTR2ADRD2USP2TSHRHTT | |
| SCHEMBL3995292 | 0.74 | ALDH1A1 (0.54) | CCR3DRD2USP2TSHRHTT | |
| SCHEMBL3997513 | 0.74 | CCR3 (0.50) | CCR3KCNH2SLC6A4 | |
| SCHEMBL4001729 | 0.72 | CCR3 (0.70) | CCR3DRD2SLC6A4 | |
| SCHEMBL13797767 | 0.70 | CCR3 (0.49) | CCR3HTR2AHTR7KCNH2DRD2 | |
| SCHEMBL4001652 | 0.70 | CCR3 (0.47) | CCR3 | |
| SCHEMBL3994282 | 0.69 | CCR3 (0.70) | CCR3DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687294-B1 | NOVEL PIPERIDINE-SUBSTITUTED INDOLES-OR HETERO-DERIVATIVES THEREOF AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR (CCR-3) | BOEHRINGER INGELHEIM INT (DE) | 2014-05-21 | — | — | EP | disclosed |
| EP-1687294-B1 | NOVEL PIPERIDINE-SUBSTITUTED INDOLES-OR HETERO-DERIVATIVES THEREOF AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR (CCR-3) | BOEHRINGER INGELHEIM INT (DE) | 2014-05-21 | — | — | EP | disclosed |
| US-7544806-B2 | Piperidine-substituted indoles-or heteroderivatives thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-09 | — | — | US | disclosed |
| US-7544806-B2 | Piperidine-substituted indoles-or heteroderivatives thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-09 | — | — | US | disclosed |
| US-20050153979-A1 | Novel piperidine-substituted indoles-or heteroderivatives thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153979-A1 | Novel piperidine-substituted indoles-or heteroderivatives thereof | CCR3, CCR1, CCR2 | CCR3 1/4885HTR2A 248/4885HTR7 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.