Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966357 | 0.96 | ITGB1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4962892 | 0.90 | MMP1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4971033 | 0.90 | MMP1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4010736 | 0.83 | HSD11B1 (0.38) | CNR2 | |
| SCHEMBL4005230 | 0.81 | ALDH1A1 (0.38) | ITGB1ITGA4ITGB7GAAALDH1A1 | |
| SCHEMBL4964632 | 0.77 | CAMK2A (0.39) | GAAL3MBTL1ALDH1A1KMT2ALMNA | |
| SCHEMBL4003682 | 0.77 | HSD11B1 (0.37) | ITGB1ITGA4ITGB7 | |
| SCHEMBL4963845 | 0.72 | ALDH1A1 (0.38) | GAAALDH1A1 | |
| SCHEMBL4006598 | 0.69 | NPSR1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4306297 | 0.69 | HSD11B1 (0.44) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |