Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003532 | 1.00 | ALDH1A1 (0.64) | ALDH1A1DPP4CCR1HSD11B1USP2 | |
| SCHEMBL4966350 | 0.96 | ALDH1A1 (0.67) | ALDH1A1DPP4CCR1HSD11B1USP2 | |
| SCHEMBL4966359 | 0.96 | ALDH1A1 (0.67) | ALDH1A1DPP4CCR1HSD11B1USP2 | |
| SCHEMBL4962889 | 0.90 | ALDH1A1 (0.63) | ALDH1A1CCR1HSD11B1 | |
| SCHEMBL4971027 | 0.90 | ALDH1A1 (0.63) | ALDH1A1CCR1HSD11B1 | |
| SCHEMBL4962896 | 0.90 | ALDH1A1 (0.63) | ALDH1A1CCR1HSD11B1 | |
| SCHEMBL4005226 | 0.82 | ALDH1A1 (0.58) | ALDH1A1USP2MAPK1LMNASMN1; SMN2 | |
| SCHEMBL4005231 | 0.82 | ALDH1A1 (0.58) | ALDH1A1USP2MAPK1LMNASMN1; SMN2 | |
| SCHEMBL5950753 | 0.82 | HSD11B1 (0.62) | ALDH1A1CCR1HSD11B1 | |
| SCHEMBL4004701 | 0.81 | HSD11B1 (0.56) | ALDH1A1HSD11B1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |