Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PPARD | Q03181 | 4/20 | 0.59 |
| ▸ | PPARA | Q07869 | 4/20 | 0.59 |
| ▸ | GRM5 | P41594 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003572 | 1.00 | ALDH1A1 (0.59) | ALDH1A1TSHRPPARDPPARAGRM5 | |
| SCHEMBL4006830 | 0.88 | PPARD (0.59) | ALDH1A1PPARDPPARAGRM5PKM | |
| SCHEMBL4006837 | 0.88 | PPARD (0.59) | ALDH1A1PPARDPPARAGRM5PKM | |
| SCHEMBL25308159 | 0.85 | MTNR1A (0.64) | PPARDPPARANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10212211 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TSHRGRM5DRD4MCHR1 | |
| SCHEMBL4005581 | 0.82 | USP30 (0.61) | PPARDPPARAPKMNPC1USP30 | |
| SCHEMBL4005574 | 0.82 | USP30 (0.61) | PPARDPPARAPKMNPC1USP30 | |
| SCHEMBL1667825 | 0.81 | RAB9A (0.73) | ALDH1A1TSHRGRM5PKMNPC1 | |
| SCHEMBL11241115 | 0.80 | RAB9A (0.75) | ALDH1A1TSHRGRM5PKMNPC1 | |
| SCHEMBL29531655 | 0.80 | ALDH1A1 (0.64) | ALDH1A1TSHRGRM5MCHR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |