Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | IL6 | P05231 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056075 | 0.89 | KIF11 (0.40) | KIF11STK17BSTK17ATLR7SIGMAR1 | |
| SCHEMBL4056076 | 0.89 | KIF11 (0.40) | KIF11STK17BSTK17ATLR7SIGMAR1 | |
| SCHEMBL4054291 | 0.81 | KIF11 (0.62) | KIF11 | |
| SCHEMBL4000396 | 0.81 | KIF11 (0.69) | KIF11 | |
| SCHEMBL4056680 | 0.78 | KIF11 (0.56) | KIF11CYP3A4 | |
| SCHEMBL5863530 | 0.77 | KIF11 (0.47) | KIF11TLR7SIGMAR1BRD4MAPT | |
| SCHEMBL4092214 | 0.77 | KIF11 (0.47) | KIF11TLR7BRD4MAPTSYK | |
| SCHEMBL4244502 | 0.77 | KIF11 (0.42) | KIF11TLR7SIGMAR1BRD4MAPT | |
| SCHEMBL4244493 | 0.77 | KIF11 (0.42) | KIF11TLR7SIGMAR1BRD4MAPT | |
| SCHEMBL4102334 | 0.76 | KIF11 (0.46) | KIF11TLR7SIGMAR1BRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074677-A2 | PYRAZOLOTRIAZINES | 4SC AG (DE) | 2009-06-18 | — | — | WO | disclosed |
| EP-2070932-A1 | Pyrazolotriazines | 4SC AG (DE) | 2009-06-17 | — | — | EP | disclosed |