Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3999745 | 0.90 | FPR2 (0.39) | MAPTALDH1A1LMNA | |
| SCHEMBL4009205 | 0.89 | ITGB1 (0.38) | MAPT | |
| SCHEMBL4006080 | 0.84 | CYP3A4 (0.39) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL4005126 | 0.83 | HSD11B1 (0.34) | MAPTKDM4EALDH1A1 | |
| SCHEMBL4010793 | 0.83 | GRM5 (0.42) | KMT2APTGS2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4010548 | 0.83 | HSD11B1 (0.38) | — | |
| SCHEMBL4006907 | 0.83 | MEN1 (0.41) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4005617 | 0.83 | ITGB1 (0.36) | MAPTKDM4E | |
| SCHEMBL4002243 | 0.83 | ALDH1A1 (0.37) | MAPTKDM4EMEN1KMT2APTGS2 | |
| SCHEMBL4009200 | 0.82 | ABCB1 (0.40) | MEN1KMT2AALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |