Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PRPS1 | P60891 | 5/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604674 | 0.93 | PRPS1 (0.39) | CDK9PRPS1HRH4 | |
| SCHEMBL604094 | 0.84 | HRH4 (0.44) | CDK9PRPS1HRH4 | |
| SCHEMBL605111 | 0.78 | SYK (0.39) | AMY1APRPS1HRH4 | |
| SCHEMBL4169750 | 0.77 | CDK9 (0.43) | CDK9PRPS1CHEK2 | |
| SCHEMBL605522 | 0.75 | SSTR5 (0.41) | HRH4SSTR5SSTR2KCNH2 | |
| SCHEMBL12057245 | 0.75 | PRPS1 (0.48) | CDK9PRPS1CHEK2 | |
| SCHEMBL605746 | 0.75 | NPBWR1 (0.41) | CBFBSSTR2KCNH2IDO1 | |
| SCHEMBL602268 | 0.74 | KDR (0.43) | AMY1ACHEK2HRH4IDO1 | |
| SCHEMBL605115 | 0.74 | HRH4 (0.50) | PRPS1HRH4SSTR5KCNH2 | |
| SCHEMBL603849 | 0.73 | F2 (0.36) | CDK9CHEK2CBFBHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009079001-A1 | BICYCLIC HETEROARYL-SUBSTITUTED IMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-25 | — | — | WO | claimed |