Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328328 | 0.85 | MEN1 (0.49) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL3060301 | 0.85 | MEN1 (0.49) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL7963283 | 0.83 | MEN1 (0.48) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL7963288 | 0.83 | MEN1 (0.48) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL6361656 | 0.74 | KMT2A (0.50) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL11469443 | 0.69 | MEN1 (0.41) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL11460981 | 0.69 | LMNA (0.36) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL9371465 | 0.69 | ADRA2A (0.54) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL13990270 | 0.69 | — | — | |
| SCHEMBL1864860 | 0.68 | NPC1 (0.50) | MEN1KMT2ANPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498321-B2 | 17β-carbothioate 17α-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents | GLAXO GROUP LIMITED (GB) | 2009-03-03 | — | — | US | claimed |