SCHEMBL400499

SCHEMBL400499

O=C(O)CNc1ccc(C(=O)O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.52
TSHR P16473 1/20 0.52
KDM4E B2RXH2 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
FNTA P49354 1/20 0.47
FNTB P49356 1/20 0.47
SRD5A2 P31213 1/20 0.46
ALDH1A1 P00352 4/20 0.46
RAB9A P51151 2/20 0.46
NPC1 O15118 1/20 0.46
HPGD P15428 1/20 0.46
AGTR1 P30556 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
AKR1C3 P42330 1/20 0.44
POLB P06746 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA3 P07451 1/20 0.44
TYR P14679 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL364406 0.98 TP53 (0.50) TP53TSHRKDM4ETDP1FNTA
SCHEMBL5692310 0.89 ALDH1A1 (0.44) ALDH1A1RAB9ANPC1HPGDAGTR1
SCHEMBL29051542 0.87 ALDH1A1 (0.46) KDM4EALDH1A1RAB9ANPC1HPGD
SCHEMBL25719356 0.84 TSHR (0.55) TP53TSHRKDM4ETDP1FNTA
SCHEMBL8639589 0.83 L3MBTL1 (0.46) TSHRKDM4ETDP1ALDH1A1RAB9A
SCHEMBL31555876 0.83 FNTA (0.49) TP53TSHRKDM4ETDP1FNTA
SCHEMBL8637256 0.83 MAPT (0.52) ALDH1A1RAB9ANPC1HPGDAGTR1
SCHEMBL12666032 0.83 TDP1 (0.49) TP53TSHRKDM4ETDP1FNTA
SCHEMBL20882094 0.82 TSHR (0.57) TP53TSHRFNTAFNTBSRD5A2
SCHEMBL9621441 0.80 KDM4E (0.47) TP53TSHRKDM4ETDP1FNTA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 440 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11938106-B2 Treatment of tinnitus using glutamate receptor agonists NORTHEAST OHIO MEDICAL UNIVERSITY (US) 2024-03-26 US claimed
US-20230038631-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIV (US) 2023-02-09 US claimed
WO-2022122668-A1 COMBINED INHIBITION OF AMINO ACID TRANSPORTERS FOR INHIBITING HUMAN PLASMACYTOID DENDRITIC CELL ACTIVITY DURING AUTOIMMUNITY MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2022-06-16 WO claimed
EP-4008330-A1 COMBINED INHIBITION OF AMINO ACID TRANSPORTERS FOR INHIBITING HUMAN PLASMACYTOID DENDRITIC CELL ACTIVITY DURING AUTOIMMUNITY Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2022-06-08 EP claimed
US-11304917-B2 Treatment of tinnitus using glutamate receptor agonists NORTHEAST OHIO MEDICAL UNIVERSITY (US) 2022-04-19 US claimed
US-20210251928-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIVERSITY 2021-08-19 US claimed
EP-3302493-B1 INHIBITORS OF CYSTINE-GLUTAMATE TRANSPORTER FOR USE IN TREATING OR PREVENTING SUBSTANCE-RELATED AND ADDICTIVE DISORDERS UNIV CHINA MEDICAL (TW) 2021-07-07 EP claimed
US-20210177869-A1 METHODS AND COMBINATIONS FOR MODULATING TOLERANCE TO OPIATES, OPIOIDS OR OPIOID ANALGESICS AND TREATING ACUTE AND CHRONIC PAIN CHINA MEDICAL UNIVERSITY (TW) 2021-06-17 US claimed
CN-107735094-B New use of inhibitors of cystine-glutamate transporter 中国医药大学 2021-05-28 CN claimed
CN-112839679-A Methods and combinations for modulating tolerance to opiates, opioids or opioid analgesics and treating acute and chronic pain 中国医药大学 2021-05-25 CN claimed
EP-1773306-A1 MEDICAMENT FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS Greenpharma (FR) 2007-04-18 EP claimed
WO-2006018538-A1 MEDICAMENT FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS GREENPHARMA (FR) 2006-02-23 WO claimed
US-6197820-B1 METABOTROPIC GLUTAMATE RECEPTOR AGONIST/ANTAGONIST (S)-4-CARBOXYPHENYLGLYCINE (S-4CPG), POTENTLY AND SELECTIVELY INHIBITED GLUTAMATE RELEASE FROM GLIOMA CELLS AND THEREBY PREVENTED NEUROTOXICITY, INHIBIT RELEASE OF TOXIC LEVELS OF UAB RESEARCH FOUNDATION 2001-03-06 US claimed
WO-2000062771-A1 USES OF PHENYLGLYCINE DERIVATIVES THE UAB RESEARCH FOUNDATION (US) 2000-10-26 WO claimed
EP-1038023-A1 AGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF THE UAB RESEARCH FOUNDATION (US) 2000-09-27 EP claimed
US-6013672-A ADMINISTERING TO AN INDIVIDUAL SUFFERING FROM HEAD, SPINAL CORD TRAUMA, STROKE AND EPILEPSY A THERAPEUTICALLY EFFECTIVE DOSE OF A METABOTROPIC GLUTAMATE RECEPTOR AGONIST UAB RESEARCH FOUNDATION (US) 2000-01-11 US claimed
WO-1999031268-A1 AGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF UAB RESEARCH FOUNDATION (US) 1999-06-24 WO claimed
US-5587509-A Caged caboxyl compounds and use thereof CORNELL RESEARCH FOUNDATION, INC. (US) 1996-12-24 US claimed
US-5430175-A Caged carboxyl compounds and use thereof CORNELL RESEARCH FOUNDATION, INC. (US) 1995-07-04 US claimed
WO-1995015305-A1 CAGED CARVOXYL COMPOUNDS AND THEIR USE IN CHEMICAL KINETIC INVESTIGATION OF NEUROTRANSMITTER RECEPTORS CORNELL RESEARCH FOUNDATION, INC. (US) 1995-06-08 WO claimed