SCHEMBL8637256

SCHEMBL8637256

CC(=O)c1ccc(NCC(=O)O)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.52
SMN1; SMN2 Q16637 4/20 0.52
RAB9A P51151 4/20 0.52
NPC1 O15118 3/20 0.52
TAAR1 Q96RJ0 1/20 0.52
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
ALDH1A1 P00352 5/20 0.47
HPGD P15428 2/20 0.47
AGTR1 P30556 1/20 0.47
KMT2A Q03164 4/20 0.47
POLB P06746 1/20 0.46
MEN1 O00255 3/20 0.46
HTT P42858 1/20 0.46
NLRP1 Q9C000 1/20 0.46
HSD17B10 Q99714 1/20 0.46
LMNA P02545 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetophenone SCHEMBL28104067 0.89 PKM (0.55) MAPTSMN1; SMN2RAB9ANPC1TAAR1
SCHEMBL5692310 0.85 ALDH1A1 (0.44) MAPTSMN1; SMN2RAB9ANPC1CA12
SCHEMBL400499 0.83 TP53 (0.52) MAPTSMN1; SMN2RAB9ANPC1CA12
SCHEMBL29051542 0.83 ALDH1A1 (0.46) MAPTSMN1; SMN2RAB9ANPC1CA12
SCHEMBL31722027 0.82 SMN1; SMN2 (0.71) MAPTSMN1; SMN2RAB9ANPC1TAAR1
Methane SCHEMBL364406 0.82 TP53 (0.50) MAPTSMN1; SMN2RAB9ANPC1CA12
SCHEMBL11718244 0.81 RAB9A (0.71) MAPTSMN1; SMN2RAB9ANPC1CA12
SCHEMBL6644241 0.81 HDAC2 (0.52) MAPTSMN1; SMN2RAB9ANPC1CA2
SCHEMBL11760216 0.80 SMN1; SMN2 (0.57) MAPTSMN1; SMN2RAB9ANPC1TAAR1
SCHEMBL8639589 0.80 L3MBTL1 (0.46) MAPTSMN1; SMN2RAB9ANPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4946761-A POLYMER CONTAINING CARBOXYL END GROUPS FUJI PHOTO FILM CO., LTD. (JP) 1990-08-07 US claimed
EP-4397677-A1 HUMAN INTERLEUKIN 2-POLYETHYLENE GLYCOL CONJUGATE AND USE THEREOF Novocodex Biopharmaceuticals Co., Ltd. (CN) 2024-07-10 EP disclosed
WO-2023004686-A1 UNNATURAL AMINO ACID, AND USE THEREOF, RECOMBINANT PROTEIN CONTAINING SAME, AND RECOMBINANT PROTEIN CONJUGATE 浙江新码生物医药有限公司 2023-02-02 WO disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-9428478-B2 Piperazine derivatives, compositions, and uses related thereto EMORY UNIVERSITY (US) 2016-08-30 US disclosed
US-9428478-B2 Piperazine derivatives, compositions, and uses related thereto EMORY UNIVERSITY (US) 2016-08-30 US disclosed
US-20140194422-A1 PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO EMORY UNIVERSITY (US) 2014-07-10 US disclosed
US-20140194422-A1 PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO EMORY UNIVERSITY (US) 2014-07-10 US disclosed
WO-2012173952-A1 PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO EMORY UNIVERSITY (US) 2012-12-20 WO disclosed
WO-2012173952-A1 PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO EMORY UNIVERSITY (US) 2012-12-20 WO disclosed
EP-0458485-B1 Image forming layer FUJI PHOTO FILM CO LTD (JP) 1998-07-29 EP disclosed
US-5395733-A Unsaturated polymer layer that can be decarboxylated on exposure to light and sensitizers FUJI PHOTO FILM CO., LTD. (JP) 1995-03-07 US disclosed
EP-0458485-A2 Image forming layer Fuji Photo Film Co., Ltd. (JP) 1991-11-27 EP disclosed
US-4946761-A POLYMER CONTAINING CARBOXYL END GROUPS FUJI PHOTO FILM CO., LTD. (JP) 1990-08-07 US disclosed
US-4405705-A HYDROPHILIC TOYO BOSEKI KABUSHIKI KAISHA T/A TOYOBA CO., LTD. (JP) 1983-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140194422-A1 PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO NOX4, NOX5, NOXO1 MAPT 2289/4885SMN1; SMN2 3107/4885RAB9A 3090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.