Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11584726 | 0.83 | MMP2 (0.59) | MMP2PKMMAPTALDH1A1POLB | |
| SCHEMBL6529191 | 0.82 | CYP2C9 (0.56) | MMP2PKMMAPTALDH1A1POLB | |
| SCHEMBL9491524 | 0.79 | KCNN4 (0.49) | MMP2PKMMAPTALDH1A1POLB | |
| SCHEMBL29482655 | 0.79 | KCNN4 (0.49) | MMP2PKMMAPTALDH1A1POLB | |
| SCHEMBL3928664 | 0.77 | GFER (0.69) | MMP2PKMMAPTRECQLALDH1A1 | |
| SCHEMBL7995378 | 0.76 | MMP2 (0.44) | MMP2CA1CA2PKMMAPT | |
| SCHEMBL7995381 | 0.76 | MMP2 (0.44) | MMP2CA1CA2PKMMAPT | |
| SCHEMBL27638859 | 0.76 | MAPT (0.48) | MMP2CA1CA2PKMMAPT | |
| SCHEMBL20552743 | 0.75 | ALDH1A1 (0.40) | MMP2PKMMAPTALDH1A1POLB | |
| SCHEMBL11357852 | 0.75 | MAPT (0.58) | MMP2CA1CA2PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | disclosed |