Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 17/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3772475 | 0.93 | PTGES2 (0.70) | PTGES2CA1CA2CA9 | |
| SCHEMBL3775536 | 0.78 | PTGES2 (0.64) | PTGES2WDR5 | |
| SCHEMBL3783869 | 0.78 | CA1 (0.74) | PTGES2CA1CA2CA9 | |
| SCHEMBL27944569 | 0.77 | CA1 (0.78) | PTGES2CA1CA2CA9 | |
| SCHEMBL9266314 | 0.77 | PTGES2 (0.70) | PTGES2CA1CA2CA9 | |
| SCHEMBL3788588 | 0.77 | PTGES2 (1.00) | PTGES2 | |
| SCHEMBL2740995 | 0.76 | TSHR (0.63) | PTGES2WDR5 | |
| SCHEMBL3776974 | 0.76 | PTGES2 (0.71) | PTGES2WDR5 | |
| SCHEMBL7594368 | 0.76 | WDR5 (0.60) | PTGES2WDR5 | |
| SCHEMBL101963 | 0.75 | ALDH1A1 (0.52) | CA1CA2CA9WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234993-A1 | BIS- (SULF ONYLAMINO) DERIVATIVES FOR USE IN THERAPY | AstraZeneca AB (SE) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009082347-A1 | BIS- (SULF ONYLAMINO) DERIVATIVES FOR USE IN THERAPY | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |