Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4875167 | 0.77 | MAPT (0.46) | KDM4EALDH1A1GLAHPGDCASP1 | |
| SCHEMBL4010186 | 0.76 | SMN1; SMN2 (0.43) | KDM4EALDH1A1SMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL21483573 | 0.73 | NPC1 (0.47) | DPP4NOS2KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL28782153 | 0.72 | MEN1 (0.49) | DPP4NOS3NOS1NOS2KDM4E | |
| SCHEMBL234452 | 0.71 | ACHE (0.47) | KDM4EALDH1A1GLAHPGDCASP1 | |
| SCHEMBL8087257 | 0.70 | CYP1A2 (0.46) | LOXL2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29133411 | 0.68 | DHODH (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2ACHE | |
| SCHEMBL4875157 | 0.68 | RAB9A (0.46) | NOS2KDM4EALDH1A1GLAHPGD | |
| SCHEMBL8090146 | 0.68 | ALDH1A1 (0.38) | KDM4EALDH1A1GLAHPGDCASP1 | |
| SCHEMBL8102371 | 0.67 | KDM4E (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009082346-A1 | NEW ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS AND USES IN TREATMENTS OF OBESITY AND DIABETES MELLITUS - 087 | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | claimed |
| WO-2009082346-A1 | NEW ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS AND USES IN TREATMENTS OF OBESITY AND DIABETES MELLITUS - 087 | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |