Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PRKACA | P17612 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | PRKCG | P05129 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769848 | 0.88 | PDE10A (0.60) | PDE10APDK4 | |
| SCHEMBL4015332 | 0.86 | PDE10A (0.51) | PDE10AALDH1A1SMN1; SMN2CDK9CCNT1 | |
| SCHEMBL4010834 | 0.84 | PDE10A (0.47) | PDE10AALDH1A1SMN1; SMN2CDK9CCNT1 | |
| SCHEMBL4014684 | 0.84 | PDE10A (0.56) | PDE10AALDH1A1SMN1; SMN2 | |
| SCHEMBL4017987 | 0.84 | PDE10A (0.45) | PDE10AALDH1A1SMN1; SMN2MAPK1TSHR | |
| SCHEMBL4010869 | 0.83 | PDE10A (0.46) | PDE10AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16992066 | 0.81 | PDE10A (0.46) | PDE10AALDH1A1SMN1; SMN2CDK9CCNT1 | |
| SCHEMBL4011858 | 0.81 | PDE10A (0.44) | PDE10ACDK9CCNT1 | |
| SCHEMBL4009606 | 0.81 | MAPT (0.45) | PDE10ACDK9CCNT1MAPT | |
| SCHEMBL4007141 | 0.81 | PDE10A (0.42) | PDE10ACDK9CCNT1CHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |