Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009648 | 0.89 | CCNT1 (0.46) | PDE10ACCNT1CDK9 | |
| SCHEMBL4009123 | 0.88 | PDE10A (0.53) | PDE10A | |
| SCHEMBL4017987 | 0.88 | PDE10A (0.45) | PDE10ATRPV1MAPK1 | |
| SCHEMBL4015332 | 0.87 | PDE10A (0.51) | PDE10ACCNT1CDK9MAPT | |
| SCHEMBL4004149 | 0.87 | HTR1A (0.48) | PDE10ACCNT1CDK9TRPV1 | |
| SCHEMBL16992066 | 0.82 | PDE10A (0.46) | PDE10ACCNT1CDK9PLK4CHEK1 | |
| SCHEMBL4013658 | 0.82 | CCNT1 (0.47) | CCNT1CDK9 | |
| SCHEMBL4555950 | 0.82 | PDE10A (0.44) | PDE10ATRPV1MAPTMAPK1 | |
| SCHEMBL4014482 | 0.82 | PDE10A (0.44) | PDE10ACCNT1CDK9TRPV1MAPT | |
| SCHEMBL4006732 | 0.81 | PDE10A (0.49) | PDE10ACCNT1CDK9MAPTPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |