Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007141 | 0.88 | PDE10A (0.42) | PDE10ATRPV1MAPK1 | |
| SCHEMBL4010759 | 0.88 | TRPV1 (0.43) | PDE10ATRPV1 | |
| SCHEMBL4007125 | 0.88 | PDE10A (0.56) | PDE10ADGAT2 | |
| SCHEMBL4014482 | 0.85 | PDE10A (0.44) | PDE10ATRPV1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4555950 | 0.85 | PDE10A (0.44) | PDE10ATRPV1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4015332 | 0.84 | PDE10A (0.51) | PDE10AALDH1A1SMN1; SMN2 | |
| SCHEMBL4004149 | 0.84 | HTR1A (0.48) | PDE10ATRPV1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4006732 | 0.84 | PDE10A (0.49) | PDE10AALDH1A1SMN1; SMN2ALOX15TSHR | |
| SCHEMBL4010834 | 0.82 | PDE10A (0.47) | PDE10AALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL4014684 | 0.82 | PDE10A (0.56) | PDE10AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |