⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297606 | 0.62 | — | — | |
| SCHEMBL12201063 | 0.59 | — | — | |
| Bromide SCHEMBL11508917 | 0.57 | HSP90AA1 (0.35) | — | |
| Bromide SCHEMBL11510071 | 0.57 | HSP90AA1 (0.35) | — | |
| SCHEMBL11335852 | 0.56 | — | — | |
| SCHEMBL5796938 | 0.51 | — | — | |
| SCHEMBL9481507 | 0.50 | — | — | |
| SCHEMBL1263979 | 0.50 | — | — | |
| SCHEMBL18917295 | 0.49 | KDM4E (0.48) | — | |
| SCHEMBL12611233 | 0.46 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281086-A1 | 2 -OXYHETEROARYLAMIDE DERIVATIVES AS PARP INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| EP-2041110-A1 | 2 -OXYHETEROARYLAMIDE DERIVATIVES AS PARP INHIBITORS | Kudos Pharmaceuticals Limited (GB) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007144637-A1 | 2 -OXYHETEROARYLAMIDE DERIVATIVES AS PARP INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2007-12-21 | — | — | WO | disclosed |