Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008655 | 1.00 | CHRM5 (0.46) | CHRM5CHKAKMT2AKDM4EMAPT | |
| SCHEMBL725900 | 0.79 | FAAH (0.45) | KMT2AKDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL725899 | 0.79 | FAAH (0.45) | KMT2AKDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL48868 | 0.72 | PLG (0.52) | CHRM5CHKAKMT2AKDM4EMAPT | |
| SCHEMBL25137294 | 0.70 | FAAH (0.48) | KMT2AKDM4ESMN1; SMN2MEN1NPC1 | |
| SCHEMBL14344787 | 0.68 | CHRM5 (0.52) | CHRM5CHKAKMT2AKDM4EMAPT | |
| SCHEMBL4385687 | 0.68 | KMT2A (0.53) | CHRM5CHKAKMT2AKDM4EMAPT | |
| SCHEMBL481904 | 0.68 | KDM4E (0.58) | CHRM5CHKAKMT2AKDM4EMAPT | |
| SCHEMBL29587923 | 0.67 | — | — | |
| SCHEMBL429504 | 0.67 | KDM4E (0.52) | CHRM5CHKAKMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074678-A2 | ANTICANCER CONJUGATES OF CAMPTOTHECIN TO HYALURONIC ACID | EURAND PHARMACEUTICALS LIMITED (IE) | 2009-06-18 | — | — | WO | claimed |
| WO-2009074678-A2 | ANTICANCER CONJUGATES OF CAMPTOTHECIN TO HYALURONIC ACID | EURAND PHARMACEUTICALS LIMITED (IE) | 2009-06-18 | — | — | WO | disclosed |