Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23519064 | 0.81 | PPARG (0.51) | PPARGPPARAMRGPRX4KDM4EHTT | |
| SCHEMBL3372794 | 0.78 | PPARG (0.51) | PPARGPPARAMRGPRX4KDM4EKMT2A | |
| SCHEMBL11570463 | 0.74 | KDM4E (0.50) | PPARGPPARAMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL11848431 | 0.74 | PPARG (0.54) | PPARGPPARAMRGPRX4KDM4EHTT | |
| SCHEMBL7823689 | 0.73 | PPARG (0.47) | PPARGPPARAMRGPRX4KDM4EHTT | |
| SCHEMBL11527555 | 0.73 | KIF11 (0.51) | PPARGPPARAKDM4EMAPTCES2 | |
| Hydrochloric Acid SCHEMBL11848416 | 0.72 | PPARG (0.52) | PPARGPPARAMRGPRX4KDM4EHTT | |
| SCHEMBL1124259 | 0.72 | PRSS1 (0.52) | PPARGPPARAMRGPRX4KDM4EHTT | |
| SCHEMBL9494172 | 0.72 | PRSS1 (0.67) | PPARGPPARAMRGPRX4KMT2AALDH1A1 | |
| SCHEMBL10566944 | 0.72 | KDM4E (0.48) | PPARGPPARAMRGPRX4KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143172-B | DCC-mediated coupling for lipid lowering amide production | 西玛贝医药公司 | 2016-12-14 | — | — | CN | disclosed |
| EP-2775835-A1 | METHODS FOR TREATING GOUT IN PATIENT SUBPOPULATIONS | METABOLEX, INC. (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013066352-A1 | METHODS FOR TREATING GOUT IN PATIENT SUBPOPULATIONS | METABOLEX, INC. (US) | 2013-05-10 | — | — | WO | disclosed |
| EP-1343493-A4 | USE OF(-) (3-HALOMETHYLPHENOXY) (4-HALOPHENYL) ACETIC ACID DERIVATIVES FOR TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, HYPERLIPIDEMIA AND HYPERURICEMIA | METABOLEX INC (US) | 2009-06-24 | — | — | EP | disclosed |
| EP-1937620-A2 | RESOLUTION OF ALPHA-(PHENOXY) PHENYLACETIC ACID DERIVATIVES WITH NAPHTHYL-ALKYLAMINES | Metabolex Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007038277-A2 | RESOLUTION OF ALPHA-(PHENOXY) PHENYLACETIC ACID DERIVATIVES WITH NAPHTHYL-ALKYLAMINES | METABOLEX, INC. (US) | 2007-04-05 | — | — | WO | disclosed |
| EP-1343493-A2 | USE OF(-) (3-HALOMETHYLPHENOXY) (4-HALOPHENYL) ACETIC ACID DERIVATIVES FOR TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, HYPERLIPIDEMIA AND HYPERURICEMIA | METABOLEX, INC. (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002044113-A9 | USE OF(-) (3-HALOMETHYLPHENOXY) (4-HALOPHENYL) ACETIC ACID DERIVATIVES FOR TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, HYPERLIPIDEMIA AND HYPERURICEMIA | METABOLEX INC (US) | 2003-05-01 | — | — | WO | disclosed |
| WO-2002044113-A2 | USE OF(-) (3-HALOMETHYLPHENOXY) (4-HALOPHENYL) ACETIC ACID DERIVATIVES FOR TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, HYPERLIPIDEMIA AND HYPERURICEMIA | METABOLEX, INC. (US) | 2002-06-06 | — | — | WO | disclosed |