Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | ACR | P10323 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11860150 | 0.85 | PRSS1 (0.55) | PRSS1ACRPPARGKDM4ECES2 | |
| SCHEMBL30116329 | 0.85 | PRSS1 (0.55) | PRSS1ACRPPARGKDM4ECES2 | |
| SCHEMBL11904756 | 0.85 | PRSS1 (0.55) | PRSS1ACRPPARGKDM4ECES2 | |
| SCHEMBL10798058 | 0.84 | KMT2A (0.42) | PRSS1ACRPPARGKDM4EATM | |
| SCHEMBL18697300 | 0.84 | PRSS1 (0.54) | PRSS1ACRPPARGKDM4ECES2 | |
| SCHEMBL11848431 | 0.84 | PPARG (0.54) | PRSS1ACRPPARGKDM4ECES2 | |
| SCHEMBL11344203 | 0.83 | PRSS1 (0.48) | PRSS1ACRPPARGKDM4ECES2 | |
| SCHEMBL10732623 | 0.82 | PRSS1 (0.52) | PRSS1ACRPPARGKDM4ECES2 | |
| Hydrochloric Acid SCHEMBL11848416 | 0.82 | PPARG (0.52) | PRSS1ACRPPARGKDM4ECES2 | |
| SCHEMBL29920925 | 0.82 | MEN1 (0.66) | PRSS1ACRPPARGKDM4ECES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107530349-B | Xanthine substituted alkynyl carbamates/trans carbamates as A2B antagonists | 路易斯和克拉克制药公司 | 2021-01-08 | — | — | CN | disclosed |
| EP-3280417-B1 | XANTHINE-SUBSTITUTED ALKYNYL CARBAMATES/REVERSE CARBAMATES AS A2B ANTAGONISTS | LEWIS AND CLARK PHARMACEUTICALS INC (US) | 2020-07-29 | — | — | EP | disclosed |
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-2920171-B1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME (US) | 2018-08-29 | — | — | EP | disclosed |
| EP-3280417-A1 | XANTHINE-SUBSTITUTED ALKYNYL CARBAMATES/REVERSE CARBAMATES AS A2B ANTAGONISTS | Lewis and Clark Pharmaceuticals, Inc. (US) | 2018-02-14 | — | — | EP | disclosed |
| US-9730940-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730940-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730940-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME (US) | 2017-08-15 | — | — | US | disclosed |
| US-9593118-B2 | Xanthine-substituted alkynyl carbamates/reverse carbamates as A2B antagonists | LEWIS AND CLARK PHARMACEUTICALS, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| EP-2328886-B1 | DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS | PF MEDICAMENT (FR) | 2016-12-28 | — | — | EP | disclosed |
| US-20040019039-A1 | Substituted piperazines and diazepanes | HIGH POINT PHARMACEUTICALS, LLC | 2004-01-29 | — | — | US | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| WO-2003051842-A2 | COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003004480-A2 | SUBSTITUTED PIPERAZINE AND DIAZEPANES AS HISTAMINE H3 RECEPTOR AGONISTS | NOVO NORDISK A/S (DK) | 2003-01-16 | — | — | WO | disclosed |
| US-20020052295-A1 | Diacyl derivatives of propylene diamine having herbicidal activity | MONSANTO TECHNOLOGY LLC | 2002-05-02 | — | — | US | disclosed |
| WO-2001046152-A1 | HERBICIDAL DIACYL DERIVATIVES OF PROPYLENE DIAMINE | MONSANTO TECHNOLOGY LLC (US) | 2001-06-28 | — | — | WO | disclosed |
| US-4618364-A | 3-(2-tetrahydropyranyl)-1,2,3,4,5,6,7-hexahydro-1-p-tolyloxycarbonyl-5H-cyclopentapyrimidine-2,4-dione and herbicidal compositions and methods using it | ROUSSEL UCLAF (FR) | 1986-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | LIPE, PNLIP, LPL | PRSS1 102/4885ACR 1819/4885PPARG 184/4885 |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | LIPE, PNLIP, LPL | PRSS1 88/4885ACR 1660/4885PPARG 293/4885 |
| US-20040019039-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | PRSS1 1299/4885ACR 4368/4885PPARG 673/4885 |
| US-20020052295-A1 | Diacyl derivatives of propylene diamine having herbicidal activity | DDT, SAT1, AOC1 | PRSS1 4648/4885ACR 1124/4885PPARG 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.