Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056868 | 0.87 | ADORA3 (0.43) | ADORA3ADORA1HDAC1HDAC8MEN1 | |
| SCHEMBL4002703 | 0.81 | MEN1 (0.42) | ADORA3ADORA1HDAC1HDAC8MEN1 | |
| SCHEMBL4055433 | 0.78 | HPGD (0.44) | ADORA3ADORA1HDAC1HDAC8MEN1 | |
| SCHEMBL4048837 | 0.74 | PDE1B (0.42) | ADORA3ADORA1HDAC1HDAC8MEN1 | |
| SCHEMBL4249080 | 0.71 | KDM4E (0.40) | MEN1KMT2ALMNAHPGDKDM4E | |
| SCHEMBL4249182 | 0.70 | KMT2A (0.51) | MEN1KMT2ALMNAHPGDKDM4E | |
| SCHEMBL4003850 | 0.70 | ADORA3 (0.40) | ADORA3ADORA1HPGDALDH1A1 | |
| SCHEMBL4248801 | 0.69 | KDM4E (0.40) | MEN1KMT2ALMNAHPGDKDM4E | |
| SCHEMBL4248798 | 0.69 | KDM4E (0.40) | MEN1KMT2ALMNAHPGDKDM4E | |
| SCHEMBL4091105 | 0.68 | PDE4A (0.51) | HDAC1HDAC8MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074677-A2 | PYRAZOLOTRIAZINES | 4SC AG (DE) | 2009-06-18 | — | — | WO | disclosed |
| EP-2070932-A1 | Pyrazolotriazines | 4SC AG (DE) | 2009-06-17 | — | — | EP | disclosed |