Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051944 | 0.80 | PDE1B (0.39) | PDE1BADORA3ADORA1PDE4APDE4B | |
| SCHEMBL4008102 | 0.80 | PDE1B (0.39) | PDE1BADORA3ADORA1PDE4APDE4B | |
| SCHEMBL4055433 | 0.80 | HPGD (0.44) | PDE1BMEN1LMNAKMT2AHDAC1 | |
| SCHEMBL4056161 | 0.79 | PDE1B (0.39) | PDE1BMEN1KMT2AADORA3ADORA1 | |
| SCHEMBL4056155 | 0.79 | PDE1B (0.39) | PDE1BMEN1KMT2AADORA3ADORA1 | |
| SCHEMBL4002703 | 0.78 | MEN1 (0.42) | PDE1BMEN1LMNAKMT2ATP53 | |
| SCHEMBL4054540 | 0.77 | PDE1B (0.39) | PDE1BMEN1KMT2AMAPTPDE4A | |
| SCHEMBL4009041 | 0.74 | ADORA3 (0.41) | PDE1BMEN1LMNAKMT2AHDAC1 | |
| SCHEMBL4056868 | 0.71 | ADORA3 (0.43) | MEN1LMNAKMT2AHDAC1HDAC8 | |
| SCHEMBL5106062 | 0.71 | PDE4A (0.51) | MEN1LMNAKMT2ATP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074677-A2 | PYRAZOLOTRIAZINES | 4SC AG (DE) | 2009-06-18 | — | — | WO | disclosed |
| EP-2070932-A1 | Pyrazolotriazines | 4SC AG (DE) | 2009-06-17 | — | — | EP | disclosed |