Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27594626 | 0.81 | TRPV1 (0.56) | NPC1RAB9ASMN1; SMN2CA2DYRK1A | |
| SCHEMBL9621110 | 0.80 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1DYRK1A | |
| SCHEMBL7933450 | 0.79 | CA2 (0.81) | CA2 | |
| SCHEMBL31276816 | 0.78 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL95067 | 0.78 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL95066 | 0.77 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8107956 | 0.77 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL30747343 | 0.76 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL20481983 | 0.76 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL14470489 | 0.76 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| CN-1196699-C | Benzazoles: benzoxazole, benzthiazole and benzimidazole derivatives | ZENECA LTD (GB) | 2005-04-13 | — | — | CN | disclosed |
| CN-1320124-A | Benzazoles: benzoxazole, benzthiazole and benzimidazole derivatives | ZENECA LTD (GB) | 2001-10-31 | — | — | CN | disclosed |