SCHEMBL4009983

SCHEMBL4009983

O=C(O)Nc1ccccc1-c1ccc(O)c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.53
HCAR2 Q8TDS4 1/20 0.48
THRA P10827 2/20 0.46
THRB P10828 2/20 0.46
MCL1 Q07820 3/20 0.46
ADORA2A P29274 1/20 0.46
ADORA1 P30542 1/20 0.46
ALDH1A1 P00352 5/20 0.45
KDM4E B2RXH2 3/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
LMNA P02545 2/20 0.43
KMT2A Q03164 1/20 0.43
PTGS2 P35354 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
HPGD P15428 1/20 0.42
CYP2C19 P33261 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16438560 0.88 PTGER1 (0.52) ALDH1A1KDM4EL3MBTL1LMNAKMT2A
SCHEMBL17797032 0.84 CHRM3 (0.51) ESR2ALDH1A1KDM4EL3MBTL1LMNA
SCHEMBL3904133 0.84 CHRM3 (0.53) ALDH1A1KDM4EL3MBTL1LMNAKMT2A
SCHEMBL4018340 0.82 ACMSD (0.50) HCAR2MCL1ALDH1A1KDM4ELMNA
SCHEMBL4019505 0.81 CHRM3 (0.53) ESR2ALDH1A1KDM4ELMNAKMT2A
SCHEMBL5099460 0.79 TDP1 (0.57) THRBALDH1A1KDM4EL3MBTL1LMNA
SCHEMBL5113547 0.79 MAPT (0.49) ALDH1A1KDM4EL3MBTL1LMNAKMT2A
SCHEMBL3913042 0.78 CHRM1 (0.56) THRBALDH1A1KDM4EL3MBTL1LMNA
SCHEMBL16438501 0.78 ALDH1A1 (0.49) THRBALDH1A1KDM4EL3MBTL1LMNA
SCHEMBL5106705 0.77 ALDH1A1 (0.55) ALDH1A1KDM4EL3MBTL1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074094-A1 SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS Pfizer Limited (GB) 2009-07-01 EP claimed
WO-2008041095-A1 SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS PFIZER LIMITED (GB) 2008-04-10 WO claimed
EP-2074094-A1 SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS Pfizer Limited (GB) 2009-07-01 EP disclosed
WO-2008041095-A1 SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS PFIZER LIMITED (GB) 2008-04-10 WO disclosed