Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SELL | P14151 | 2/20 | 0.44 |
| ▸ | SELP | P16109 | 2/20 | 0.44 |
| ▸ | SELE | P16581 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681312 | 0.88 | CHRM3 (0.50) | ACMSDLMNARAB9ANTRK1HTT | |
| SCHEMBL17797038 | 0.85 | CHRM3 (0.53) | LMNAKDM4ERAB9ANTRK1HTT | |
| SCHEMBL17797001 | 0.83 | CHRM3 (0.52) | LMNAKDM4EHSD17B10RAB9ANTRK1 | |
| SCHEMBL4009983 | 0.82 | ESR2 (0.53) | HCAR2LMNAKDM4EMCL1SELL | |
| SCHEMBL3906948 | 0.82 | LMNA (0.46) | LMNAKDM4EHSD17B10RAB9ANTRK1 | |
| SCHEMBL16438538 | 0.81 | LMNA (0.43) | LMNAKDM4ERAB9ANTRK1HTT | |
| SCHEMBL3904133 | 0.81 | CHRM3 (0.53) | LMNAKDM4ERAB9AMEN1ALDH1A1 | |
| SCHEMBL3910619 | 0.79 | ALDH1A1 (0.57) | LMNAKDM4ERAB9ANTRK1HTT | |
| SCHEMBL3904710 | 0.79 | RAB9A (0.52) | ACMSDLMNAKDM4ERAB9AHTT | |
| SCHEMBL17796942 | 0.78 | CHRM3 (0.53) | LMNARAB9ANTRK1HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074094-A1 | SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS | Pfizer Limited (GB) | 2009-07-01 | — | — | EP | claimed |
| WO-2008041095-A1 | SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | claimed |
| EP-2074094-A1 | SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS | Pfizer Limited (GB) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008041095-A1 | SULFONAMIDE DERIVATIVES AS ADRENERGIC AGONISTS AND MUSCARINIC ANTAGONISTS | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |