Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.69 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.67 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA4 | P22748 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123175 | 0.84 | EPHX2 (0.77) | EPHX2EPHX1CXCR3ALDH1A1CA12 | |
| SCHEMBL4132566 | 0.84 | CA12 (0.71) | EPHX2EPHX1CXCR3ALDH1A1CA12 | |
| SCHEMBL2752560 | 0.82 | EPHX1 (0.97) | EPHX2EPHX1ALDH1A1KMT2ANPC1 | |
| SCHEMBL357891 | 0.82 | EPHX2 (0.67) | EPHX2EPHX1CXCR3ALDH1A1CA12 | |
| SCHEMBL1911203 | 0.82 | EPHX2 (0.67) | EPHX2EPHX1CXCR3ALDH1A1CA12 | |
| SCHEMBL2719122 | 0.81 | EPHX2 (1.00) | EPHX2EPHX1 | |
| SCHEMBL12196149 | 0.81 | EPHX1 (1.00) | EPHX2EPHX1ALDH1A1KMT2ANPC1 | |
| SCHEMBL4015336 | 0.79 | EPHX2 (0.80) | EPHX2EPHX1CXCR3 | |
| SCHEMBL3352294 | 0.79 | EPHX2 (0.73) | EPHX2USP30 | |
| SCHEMBL25094024 | 0.76 | EPHX2 (0.58) | EPHX2EPHX1ALDH1A1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | claimed |
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |