Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006522 | 0.89 | ALDH1A1 (0.38) | KMT2AALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL4005110 | 0.87 | HPGD (0.43) | KMT2AALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL4013090 | 0.86 | TAAR1 (0.39) | KMT2AALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL4012751 | 0.85 | PTGDR2 (0.40) | MAPTHTTNPSR1HPGDPTGDR2 | |
| SCHEMBL4015878 | 0.85 | HPGD (0.36) | KMT2AMAPTHTTNPSR1HPGD | |
| SCHEMBL4008415 | 0.83 | MAPT (0.41) | KMT2AALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL13963134 | 0.83 | HPGD (0.34) | MAPTHTTNPSR1HPGDPTGDR2 | |
| SCHEMBL4010032 | 0.83 | PRLHR (0.38) | MAPTHTTNPSR1HPGDPTGDR2 | |
| SCHEMBL4011802 | 0.79 | TAAR1 (0.39) | KMT2AALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL13962981 | 0.79 | TAAR1 (0.39) | KMT2AALDH1A1MAPTHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |