Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764989 | 0.80 | SLC6A2 (0.67) | SLC6A2SLC6A3SLC6A4IDO1HTR2A | |
| SCHEMBL2765367 | 0.78 | SLC6A4 (0.56) | SLC6A2SLC6A3SLC6A4IDO1TAAR1 | |
| SCHEMBL2326795 | 0.78 | SLC6A2 (0.64) | SLC6A2SLC6A3SLC6A4IDO1ACACB | |
| SCHEMBL11451578 | 0.78 | SIGMAR1 (0.43) | IDO1ACACBTAAR1HTR2AMEN1 | |
| SCHEMBL9790105 | 0.78 | IDO1 (0.44) | IDO1ACACBTAAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2320829 | 0.77 | SLC6A2 (0.57) | SLC6A2SLC6A3SLC6A4IDO1ACACB | |
| SCHEMBL6683952 | 0.77 | SLC6A3 (0.52) | SLC6A2SLC6A3SLC6A4IDO1ACACB | |
| SCHEMBL2558920 | 0.77 | SLC6A2 (0.57) | SLC6A2SLC6A3SLC6A4IDO1ACACB | |
| SCHEMBL21175025 | 0.77 | TAAR1 (0.47) | SLC6A2SLC6A3SLC6A4IDO1TAAR1 | |
| SCHEMBL22229845 | 0.76 | SLC6A2 (1.00) | SLC6A2SLC6A3SLC6A4TAAR1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074089-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008048991-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-04-24 | — | — | WO | disclosed |