Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010818 | 1.00 | KDM4E (0.60) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL610353 | 0.95 | HSD11B1 (0.65) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL612160 | 0.95 | HSD11B1 (0.65) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL4005137 | 0.92 | ALDH1A1 (0.72) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL610672 | 0.87 | KDM4E (0.59) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL610671 | 0.87 | KDM4E (0.59) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL4960307 | 0.86 | KDM4E (0.53) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL610748 | 0.86 | KDM4E (0.53) | KDM4EALDH1A1HSD11B1EPHX2KMT2A | |
| SCHEMBL4143730 | 0.86 | EPHX2 (0.78) | ALDH1A1HSD11B1EPHX2KMT2APOLB | |
| SCHEMBL4005534 | 0.84 | RAB9A (0.70) | ALDH1A1HSD11B1EPHX2KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |