Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011666 | 1.00 | HTT (0.49) | HTTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL3925107 | 0.77 | ALDH1A1 (0.52) | HTTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5096985 | 0.74 | POLB (0.49) | HTTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL5096975 | 0.74 | POLB (0.49) | HTTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL1813746 | 0.73 | ALDH1A1 (0.72) | HTTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL717339 | 0.71 | ALDH1A1 (0.53) | HTTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL16845783 | 0.70 | HTT (0.58) | HTTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL4736633 | 0.70 | HTT (0.58) | HTTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL6363704 | 0.70 | HTT (0.58) | HTTPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL14041605 | 0.70 | HTT (0.58) | HTTPOLBALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044061-A2 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | Kahraman, Mehmet (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008011560-A2 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | KAHRAMAN MEHMET (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021026-A1 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | Kahraman, Mehmet (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021026-A1 | BENZOTHIOPHENE INHIBITORS OF RHO KINASE | RHOT2, ROCK2, ROCK1 | HTT 2006/4885POLB 3413/4885ALDH1A1 3500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.