Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061877 | 0.87 | CYP1A2 (0.51) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL2448810 | 0.83 | HDAC6 (0.65) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL14228915 | 0.80 | HDAC6 (0.62) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL10596306 | 0.79 | CA12 (0.61) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL25276969 | 0.78 | CA12 (0.64) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL9435656 | 0.78 | CA12 (0.64) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL25272620 | 0.78 | HDAC6 (0.62) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL11141720 | 0.77 | HDAC6 (0.77) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL3482935 | 0.75 | HDAC6 (0.60) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL2693605 | 0.75 | CYP1A2 (0.56) | HDAC1HDAC8BCHECYP1A2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504538-B2 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | TRPA1, TRPV1, TST | HDAC6 148/4885HDAC1 407/4885HDAC3 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.