Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.43 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001581 | 0.98 | NR1H2 (0.49) | NR1H2NR1H3SYKPTGS2KCNH2 | |
| SCHEMBL3993358 | 0.83 | PTGS2 (0.54) | SYKPTGS2LRRK2PIP4K2APIP4K2C | |
| SCHEMBL30700822 | 0.79 | PTGS2 (0.46) | NR1H2NR1H3PTGS2LOXL2PIP4K2A | |
| SCHEMBL6883165 | 0.79 | PTGS2 (0.46) | NR1H2NR1H3PTGS2LOXL2PIP4K2A | |
| SCHEMBL6243674 | 0.79 | KCNH2 (0.50) | NR1H2NR1H3SYKPTGS2KCNH2 | |
| SCHEMBL30690007 | 0.78 | ALOX5 (0.53) | NR1H2NR1H3SYKKCNH2LRRK2 | |
| SCHEMBL17367960 | 0.78 | ALOX5 (0.53) | NR1H2NR1H3SYKKCNH2LRRK2 | |
| SCHEMBL24572933 | 0.77 | CAMKK2 (0.50) | NR1H2NR1H3SYKKCNH2LRRK2 | |
| SCHEMBL26104545 | 0.77 | PTGS2 (0.45) | PTGS2PIP4K2APIP4K2CPTGS1 | |
| Hydrochloric Acid SCHEMBL31280707 | 0.77 | ALOX5 (0.52) | NR1H2NR1H3SYKKCNH2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |